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A team of scientists at the University of Pittsburgh has discovered another genetic piece of the puzzle in the cause of primary lymphedema: mutations in a gap junction protein (Connexin 47). The research is based on findings from the University's Lymphedema Family Study.
Dr. Finegold, professor of human genetics at the University and principle investigator of the Lymphedema Family Study, believes research on this protein could lead ultimately to targeting the gene with drugs to improve its function.
Information on his team's findings can be found in: "GJC2 Missense Mutations Cause Human Lymphedema", The American Journal of Human Genetics (2010), do:10.1016/rajah, and in the June 2010 Lymphatic Research Foundation's le-newsletter (see contact information below).
The purpose of this site is to link people in Canada with dysfunctioning lymphatic systems with health care professionals and support groups in their communities and around the world. Through this site we will keep you informed of some of the latest developments in scientific research and treatment in this area.
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Please note that the information on this web site is presented for informational purposes only. Any mention of a product, form of therapy, or therapist does not constitute a recommendation. We are not able to answer personal questions related to medical conditions. For more information please review the links on this web site and consult your doctor.
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If you have any comments, you can contact us at info@lymphovenous-canada.ca .
Technical Advice by Nigel Allen and Vithiyiharan Ganesh.
Last revised April 14, 2012.
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